abstract：:We investigated the radiosensitizing effects of Co-NMS, a derivative of nimesulide based on a cobalt carbonyl complex, on malignant glioma cells. In the zebrafish exposed to Co-NMS ranging from 5 to 20 μM, cell death and heat shock protein 70 expression in the brain and neurobehavioral performance were evaluated. Our ...

journal_title：Journal of cellular physiology

authors： Liu Y,Zhang T,Li G,Li S,Li J,Zhao Q,Wu Q,Xu D,Hu X,Zhang L,Li Q,Zhang H,Liu B

更新日期：2020-12-01 00:00:00

abstract：:The purpose of this study was to investigate the potential mechanism of interleukin-6 (IL-6) on the stimulation of excessive androgen secretion in human NCI-H295R adrenocortical cells. We performed transcriptome sequencing of cancer and paracancerous tissues obtained from functional adrenal cortical adenomas. The secr...

journal_title：Journal of cellular physiology

authors： Wei X,Zhang J,Peng W,Xu H,Wei Z,Pang L,Liu J,Wang T

更新日期：2020-12-01 00:00:00

abstract：:Obesity, a rising public health burden, is a multifactorial disease with an increased risk for patients to develop several pathological conditions including type 2 diabetes mellitus, hypertension, and cardiovascular disease. Increasing evidence suggests a relationship between the human brain-derived neurotrophic facto...

journal_title：Journal of cellular physiology

authors： Ieraci A,Barbieri SS,Macchi C,Amadio P,Sandrini L,Magni P,Popoli M,Ruscica M

更新日期：2020-12-01 00:00:00

abstract：:Glucocorticoid-induced osteonecrosis of the femoral head (GIOFH) is one of the most common complications of glucocorticoid administration. By chelating Fe2+ , desferoxamine (DFO) was reported to be able to activate the HIF-1α/VEGF pathway and promote angiogenesis. In the present study, we examined whether DFO administ...

journal_title：Journal of cellular physiology

authors： Jing X,Du T,Yang X,Zhang W,Wang G,Liu X,Li T,Jiang Z

更新日期：2020-12-01 00:00:00

abstract：:At the end of December 2019, a novel acute respiratory syndrome coronavirus 2 (SARS-CoV2) appeared as the third unheard of outbreak of human coronavirus infection in the 21st century. First, in Wuhan, China, the novel SARS-CoV2 was named by the World Health Organization (WHO), as 2019-nCOV (COVID-19), and spread extre...

journal_title：Journal of cellular physiology

authors： Tahmasebi S,Khosh E,Esmaeilzadeh A

更新日期：2020-12-01 00:00:00

abstract：:Lung cancer is a main cause of death all over the world with a high incidence rate. Metastasis into neighboring and distant tissues as well as resistance of cancer cells to chemotherapy demand novel strategies in lung cancer therapy. Curcumin is a naturally occurring nutraceutical compound derived from Curcuma longa (...

journal_title：Journal of cellular physiology

authors： Ashrafizadeh M,Najafi M,Makvandi P,Zarrabi A,Farkhondeh T,Samarghandian S

更新日期：2020-12-01 00:00:00

abstract：:Diabetic retinopathy (DR) is complication resulted from Type 2 diabetes mellitus. Accumulating evidence has proved the functions of long noncoding RNAs (lncRNAs) in the progression of DR. Recent reports exert the numerous regulatory functions of lncRNA nuclear-enriched abundant transcript 1 (NEAT1) in various diseases...

journal_title：Journal of cellular physiology

authors： Shao K,Xi L,Cang Z,Chen C,Huang S

更新日期：2020-12-01 00:00:00

abstract：:The tumor microenvironment significantly affects tumor progression, and tumor cells can also remodel the tumor microenvironment through complex interaction. Inflammasomes are innate immune system receptors/sensors that regulate an inflammatory response mainly mediated by the nucleotide-binding oligomerization domain-l...

journal_title：Journal of cellular physiology

authors： Tu CE,Hu Y,Zhou P,Guo X,Gu C,Zhang Y,Li A,Liu S

更新日期：2020-11-23 00:00:00

abstract：:Morphine, a mu-opioid receptor (MOR) agonist, has been extensively used to treat advanced cancer pain. In particular, in patients with cancer metastasis, both morphine and anticancer drugs are given simultaneously. However, evidence showed that morphine might be a risk factor in promoting the tumor's malignant potenti...

journal_title：Journal of cellular physiology

authors： Lu H,Zhang H,Weng ML,Zhang J,Jiang N,Cata JP,Ma D,Chen WK,Miao CH

更新日期：2020-11-13 00:00:00

abstract：:Cervical cancer is the fourth most frequent cancer in women worldwide. PDZ-binding kinase (PBK) is proven to promote the malignant behaviors of various carcinomas. However, its functional roles and oncogenic mechanisms in cervical cancer are poorly understood. In this study, we reported that PBK was highly expressed i...

journal_title：Journal of cellular physiology

authors： Ma H,Han F,Yan X,Qi G,Li Y,Li R,Yan S,Yuan C,Song K,Kong B

更新日期：2020-11-13 00:00:00

abstract：:Controlled-release drug delivery systems are promising platforms in medicine. Among various types of material in drug delivery, hydrogels are interesting ones. They are water-soluble and tissue compatible polymers with a high capacity to carry and release drugs in a controllable manner. In this study, we introduce the...

journal_title：Journal of cellular physiology

authors： Davoodi-Monfared P,Akbari-Birgani S,Mohammadi S,Kazemi F,Nikfarjam N,Nikbakht M,Mousavi SA

更新日期：2020-11-05 00:00:00

abstract：:Diabetic retinopathy (DR) is the most common ocular complication caused by diabetes mellitus and is the main cause of visual impairment in working-age people. Reactive gliosis and pro-inflammatory cytokine production by Müller cells contribute to the progression of DR. Melatonin is a strong anti-inflammatory hormone, ...

journal_title：Journal of cellular physiology

authors： Tu Y,Zhu M,Wang Z,Wang K,Chen L,Liu W,Shi Q,Zhao Q,Sun Y,Wang X,Song E,Liu X

更新日期：2020-11-01 00:00:00

abstract：:Long noncoding RNA (lncRNA) NKILA has been well studied in several types of human tumors as a tumor suppressor, while its involvement in cervical squamous cell carcinoma (CSCC) remains unclear. In our studies, we found that serum NKILA was at lower levels and serum microRNA-21 (miRNA-21) was at higher levels in patien...

journal_title：Journal of cellular physiology

authors： Wang J,Zhu Z,Qiu H,Liu C,Chang X,Qi Y,Lv Q

更新日期：2020-11-01 00:00:00

abstract：:Phospholipase C-ε (PLCε) is frequently overexpressed in tumors and plays an important role in the regulation of tumorigenesis. Although great progress has been made in understanding biological roles of PLCε, the relevant molecular mechanisms underlying its pro-tumor activity remain largely unclear. Here, we demonstrat...

journal_title：Journal of cellular physiology

authors： Fan Y,Ou L,Fan J,Li L,Wang X,Niu L,Wu X,Luo C

更新日期：2020-11-01 00:00:00

abstract：:Ubiquitin-specific protease 14 (USP14) is a ubiquitin-specific protease that is associated with the proteasome and plays important roles in cellular functions, viral infection, inflammatory responses, neurodegenerative diseases, and tumorigenesis. USP14 appears to have a dual function in regulating intracellular prote...

journal_title：Journal of cellular physiology

authors： Wang D,Ma H,Zhao Y,Zhao J

更新日期：2020-11-01 00:00:00

abstract：:Lung cancer is the leading cause of cancer death worldwide. Although diagnostic methods and targeted drugs have been rapidly developed in recent years, the underlying molecular mechanisms in the pathogenesis of lung cancer remain enigmatic. The N6-methyladenosine (m6 A) modification is the most common modification of ...

journal_title：Journal of cellular physiology

authors： Xu R,Pang G,Zhao Q,Yang L,Chen S,Jiang L,Shen Y,Shao W

更新日期：2020-11-01 00:00:00

abstract：:The manipulation of autophagy provides a new opportunity for highly effective anticancer therapies. Recently, we showed that photodynamic therapy (PDT) with nitrogen-doped titanium dioxide (N-TiO2 ) nanoparticles (NPs) could promote the reactive oxygen species (ROS)-dependent autophagy in leukemia cells. However, the ...

journal_title：Journal of cellular physiology

authors： Mohammadalipour Z,Rahmati M,Khataee A,Moosavi MA

更新日期：2020-11-01 00:00:00

abstract：:We investigated the regulation of Cl- secretion by adrenoceptors in polarized 16HBE14o- human bronchial epithelial cells. Treatment with the nonselective β adrenoceptor agonist isoprenaline stimulated an increase in short-circuit current (ISC ), which was inhibited by the β adrenoceptor blocker propranolol. Treatment ...

journal_title：Journal of cellular physiology

authors： Zhang RG,Yip CY,Pan KW,Cai MY,Ko WH

更新日期：2020-11-01 00:00:00

abstract：:Nonalcoholic fatty liver disease (NAFLD) is prevalent chronic liver diseases with unknown mechanism and no curative treatment. Hepatokines have demonstrated importance in NAFLD but, role of selenoprotein P (SeP) in NAFLD is unknown. A total of 79 patients with NAFLD and 79 healthy controls were included in this case-c...

journal_title：Journal of cellular physiology

authors： Chen Y,He X,Chen X,Li Y,Ke Y

更新日期：2020-10-22 00:00:00

abstract：:Transient receptor potential vanilloid 4 (TRPV4) channels are mechanosensitive ion channels that regulate systemic endothelial cell (EC) functions such as vasodilation, permeability, and angiogenesis. TRPV4 is expressed in retinal ganglion cells, Müller glia, pigment epithelium, microvascular ECs, and modulates cell v...

journal_title：Journal of cellular physiology

authors： Cappelli HC,Guarino BD,Kanugula AK,Adapala RK,Perera V,Smith MA,Paruchuri S,Thodeti CK

更新日期：2020-10-20 00:00:00

abstract：:Cornea is an avascular and transparent tissue that focuses light on retina. Cornea is supported by the corneal-endothelial layer through regulation of hydration homeostasis. Restoring vision in patients afflicted with corneal endothelium dysfunction-mediated blindness most often requires corneal transplantation (CT), ...

journal_title：Journal of cellular physiology

authors： Khalili M,Asadi M,Kahroba H,Soleyman MR,Andre H,Alizadeh E

更新日期：2020-10-08 00:00:00

abstract：:Mesenchymal stromal cells (MSCs) have been widely exploited for the treatment of several conditions due to their intrinsic regenerative and immunomodulatory properties. MSC have demonstrated to be particularly relevant for the treatment of ischemic diseases, where MSC-based therapies can stimulate angiogenesis and ind...

journal_title：Journal of cellular physiology

authors： Pinto DS,Ahsan T,Serra J,Fernandes-Platzgummer A,Cabral JMS,da Silva CL

更新日期：2020-10-01 00:00:00

abstract：:Adipose-derived stem cells (ADSCs) are a type of mesenchymal stem cells isolated from adipose tissue and have the ability to differentiate into adipogenic, osteogenic, and chondrogenic lineages. Despite their great therapeutic potentials, previous studies showed that ADSCs could enhance the proliferation and metastati...

journal_title：Journal of cellular physiology

authors： Chan YW,So C,Yau KL,Chiu KC,Wang X,Chan FL,Tsang SY

更新日期：2020-10-01 00:00:00

abstract：:Resistance to tamoxifen remains a prominent conundrum in the therapy of hormone-sensitive breast cancer. Also, the molecular underpinnings leading to tamoxifen resistance remain unclear. In the present study, we utilized the Gene Expression Omnibus database to identify that SOX11 might exert a pivotal function in conf...

journal_title：Journal of cellular physiology

authors： Xiao Y,Xie Q,Qin Q,Liang Y,Lin H,Zeng

更新日期：2020-10-01 00:00:00

abstract：:Parkinson's disease (PD) is one of the most common movement disorders with loss of dopaminergic neurons and the presence of Lewy bodies in certain brain areas. However, it is not clear how Lewy body (inclusion with protein aggregation) formation occurs. Mutations in leucine-rich repeat kinase 2 (LRRK2) can cause a gen...

journal_title：Journal of cellular physiology

authors： Thomas JM,Wang X,Guo G,Li T,Dai B,Nucifora LG,Nucifora FC Jr,Liu Z,Xue F,Liu C,Ross CA,Smith WW

更新日期：2020-10-01 00:00:00

abstract：:Breast cancer stem cells (BCSCs) are competent to initiate tumor formation and growth and refractory to conventional therapies. Consequently BCSCs are implicated in tumor recurrence. Many signaling cascades associated with BCSCs are critical for epithelial-to-mesenchymal transition (EMT). We developed a model system t...

journal_title：Journal of cellular physiology

authors： Fritz AJ,Hong D,Boyd J,Kost J,Finstaad KH,Fitzgerald MP,Hanna S,Abuarqoub AH,Malik M,Bushweller J,Tye C,Ghule P,Gordon J,Frietze S,Zaidi SK,Lian JB,Stein JL,Stein GS

更新日期：2020-10-01 00:00:00

abstract：:The activation of the Wnt/β-catenin signaling pathway is critical for skeletal development but surprisingly little is known about the requirements for the specific frizzled (Fzd) receptors that recognize Wnt ligands. To define the contributions of individual Fzd proteins to osteoblast function, we profiled the express...

journal_title：Journal of cellular physiology

authors： Kushwaha P,Kim S,Foxa GE,Michalski MN,Williams BO,Tomlinson RE,Riddle RC

更新日期：2020-10-01 00:00:00

abstract：:High temperature requirement A1 (HTRA1) is a serine protease playing a modulatory role in various cell processes, particularly in the regulation of transforming growth factor-β (TGF-β) signaling. A deleterious role in late-onset cerebral small vessel diseases (CSVDs) of heterozygous HTRA1 mutations, otherwise causativ...

journal_title：Journal of cellular physiology

authors： Fasano A,Formichi P,Taglia I,Bianchi S,Di Donato I,Battisti C,Federico A,Dotti MT

更新日期：2020-10-01 00:00:00

abstract：:Long noncoding RNAs (lncRNAs) have been shown to have critical regulatory roles in tumorigenesis. lncRNA LINC01561 (LINC01561) is a newly identified tumor-related lncRNA and its dysregulation has been demonstrated in several tumors. However, whether LINC01561 is involved in the progression of non-small-cell lung carci...

journal_title：Journal of cellular physiology

authors： Gao W,Qi CQ,Feng MG,Yang P,Liu L,Sun SH

更新日期：2020-10-01 00:00:00

abstract：:Acute respiratory distress syndrome (ARDS), characterized by acute hypoxic respiratory dysfunction or failure, is a manifestation of multiple organ failure in the lung, and the most common risk factor is sepsis. We previously showed that blocking α2 -adrenoceptor (α2 -AR) could attenuate lung injury induced by endotox...

journal_title：Journal of cellular physiology

authors： Cong Z,Li D,Tao Y,Lv X,Zhu X

更新日期：2020-10-01 00:00:00

abstract：:Tumor cells secrete extracellular vesicles (EVs) for intercellular communication. EVs by transporting different proteins, nucleic acids, and lipids contribute to affect target cell function and fate. ‎EVs which originate directly from multivesicular bodies so-called exosomes have dramatically fascinated the attention ...

journal_title：Journal of cellular physiology

authors： Jabbari N,Akbariazar E,Feqhhi M,Rahbarghazi R,Rezaie J

更新日期：2020-10-01 00:00:00

abstract：:Resistance to conventional chemotherapy remains a major cause of cancer relapse and cancer-related deaths. Therefore, there is an urgent need to overcome resistance barriers. To improve cancer treatment approaches, it is critical to elucidate the basic mechanisms underlying drug resistance. Increasingly, the mechanism...

journal_title：Journal of cellular physiology

authors： Naghizadeh S,Mohammadi A,Duijf PHG,Baradaran B,Safarzadeh E,Cho WC,Mansoori B

更新日期：2020-10-01 00:00:00

abstract：:Alkaptonuria (AKU) is a rare disease correlated with deficiency of the enzyme homogentisate 1,2 dioxygenase, which causes homogentisic acid (HGA) accumulation. HGA is subjected to oxidation/polymerization reactions, leading to the production of a peculiar melanin-like pigmentation (ochronosis) after chronic inflammati...

journal_title：Journal of cellular physiology

authors： Schiavone ML,Millucci L,Bernardini G,Giustarini D,Rossi R,Marzocchi B,Santucci A

更新日期：2020-10-01 00:00:00

abstract：:Numerous studies have suggested that urothelial cancer-associated 1 (UCA1) acts as a suppressor gene affecting cell proliferation and migration. However, the biological role and the potential mechanism of UCA1 in the progression of pre-eclampsia (PE) remains unclear. The UCA1 level was markedly upregulated in PE pregn...

journal_title：Journal of cellular physiology

authors： Liu J,Luo C,Zhang C,Cai Q,Lin J,Zhu T,Huang X

更新日期：2020-10-01 00:00:00

abstract：:Fibrosis is a common pathological condition associated with abnormal repair after tissue injury. However, the etiology and molecular mechanisms of fibrosis are still not well-understood. Tumor necrosis factor (TNF)-like weak inducer of apoptosis (TWEAK) belongs to the TNF superfamily and acts by binding to its recepto...

journal_title：Journal of cellular physiology

authors： Zhang Y,Zeng W,Xia Y

更新日期：2020-09-30 00:00:00

abstract：:Priapism, a prolonged penile erection in the absence of sexual arousal, is common among patients with sickle cell disease (SCD). Hypogonadism is also common in patients with SCD. While the administration of exogenous testosterone reverses hypogonadism, it is contraceptive. We hypothesized that the stimulation of endog...

journal_title：Journal of cellular physiology

authors： Musicki B,Karakus S,La Favor JD,Chen H,Silva FH,Sturny M,Zirkin BR,Burnett AL

更新日期：2020-09-24 00:00:00

abstract：:Glioblastoma (GBM) is the most common, malignant, and deadly primary glioma. Six-transmembrane epithelial antigen of prostate (STEAP) family is involved in tumorigenesis; here, we have explored the biological function and the prognostic value of the STEAP family in GBM. Differentially expressed STEAP genes in tumor an...

journal_title：Journal of cellular physiology

authors： Chen H,Xu C,Yu Q,Zhong C,Peng Y,Chen J,Chen G

更新日期：2020-09-23 00:00:00

abstract：:In this study, we used a bioinformatics approach to analyze the nucleotide composition and pattern of synonymous codon usage in mitochondrial ND genes in three amphibian groups, that is, orders Anura, Caudata, and Gymnophiona to identify the commonality and the differences of codon usage as no research work was report...

journal_title：Journal of cellular physiology

authors： Barbhuiya PA,Uddin A,Chakraborty S

更新日期：2020-09-22 00:00:00

abstract：:COVID-19, a new disease caused by the 2019-novel coronavirus (SARS-CoV-2), has swept the world and challenged its culture, economy, and health infrastructure. Forced emergence to find an effective vaccine to immunize people has led scientists to design and examine vaccine candidates all over the world. Until a vaccine...

journal_title：Journal of cellular physiology

authors： Rezaei M,Ziai SA,Fakhri S,Pouriran R

更新日期：2020-09-09 00:00:00

abstract：:Septins play important roles in regulating development and differentiation. Septin 7 (SEPT7) is a crucial component in orchestrating the septin core complex into highly ordered filamentous structures. Here, we showed that genetic depletion of SEPT7 or treatment with forchlorfenuron (FCF; a compound known to affect sep...

journal_title：Journal of cellular physiology

authors： Chen TY,Lin TC,Kuo PL,Chen ZR,Cheng HL,Chao YY,Syu JS,Lu FI,Wang CY

更新日期：2020-09-01 00:00:00